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Scientists discover how the brain wakes you up from sleep

The mystery of sleep is yet to be uncovered but scientists at the University of Bern have unveiled an interesting fact about our brain function that helps to wake up from sleep. The part of the brain that is responsible for terminating the sleep by non-rapid eye movement (NREM) cycle has been identified by Professor Antoine Adamantidis. Prof. Adamantidis is leading the team working on the neural circuit of sleep. It has been found that there exists a neural circuit between the hypothalamas and thalamas of the brain which responds to light pulse.

Scientists discover how the brain wakes you up from sleep

The experiment was carried on mice where an optogenetic technique was applied on the mice which induced sudden awakenings whereas a more intensified effort caused prolonged awakenings. The discovery is immensely important not just because it helped scientists to decode the conundrum of sleep, but because it can also be used to cure several brain diseases.

The revelation can be implemented to cure coma patients back to consciousness or even persons suffering from lack of sleep. Electric or light pulses are induced in order to study the neural circuit. Electric stimulation has been used for curing brain related problems since a ling time but without detailed understanding. Now with unwinding a new knot, more new doors of possibilities have been opened for neuro science.

“Even though we made an important step forward now, it will take some time before novel therapeutical strategies will be designed based on our results,” Adamantidis said. This means we have to wait some more time before getting a fruitful innovation coming to us.

The Abstract is stated below:

During non-rapid eye movement (NREM) sleep, synchronous synaptic activity in the thalamocortical network generates predominantly low-frequency oscillations (<4 Hz) that are modulated by inhibitory inputs from the thalamic reticular nucleus (TRN). Whether TRN cells integrate sleep-wake signals from subcortical circuits remains unclear. We found that GABA neurons from the lateral hypothalamus (LHGABA) exert a strong inhibitory control over TRN GABA neurons (TRNGABA). We found that optogenetic activation of this circuit recapitulated state-dependent changes of TRN neuron activity in behaving mice and induced rapid arousal during NREM, but not REM, sleep. During deep anesthesia, activation of this circuit induced sustained cortical arousal. In contrast, optogenetic silencing of LHGABA-TRNGABA transmission increased the duration of NREM sleep and amplitude of delta (1–4 Hz) oscillations. Collectively, these results demonstrate that TRN cells integrate subcortical arousal inputs selectively during NREM sleep and may participate in sleep intensity.

Source: Nature

Nick is a Cloud Architect by profession. He loves to spend a lot of time testing and reviewing the latest gadgets and software. He likes all things tech and his passion for smartphones is only matched by his passion for Sci-Fi TV Series.

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